The Freedge contains food that needs to be refrigerated. Additionally, the pantry also contains a variety of toiletries and in the colder months, hats, gloves and socks. The pantry contains non-perishable food items such as pasta, rice, and beans, as well as cereal, canned vegetables, and snacks. The pantry and Freedge are located outside the bookstore and are accessible 24 hours a day. In addition to the plant share, the bookstore hosts and maintains a Freedge, a community refrigerator, and also has a Little Free Pantry. Wilton man among four killed in Long Island head-on crash, police said.Lamont wants to cut taxes for more than a million CT residents.Paul McCartney talks ‘magic’ of lyrics, still writing with John Lennon during Yale conversation.Can you fly from Connecticut with cannabis?.Pair banned from Enfield schools after sending letters to officials, town manager says.How UConn women's basketball transfer Lou Lopez Sénéchal became leader of Huskies: 'Remarkable'.Eversource doubles pay for CEO as 'skyrocketing' electric bills hit customers.Starting in April the bookstore plans to host in-person plant swap days where people can come and share plants and, added Bennett, “hopefully make new friends.” They also have several other projects in the works designed to help the community. Bennett encourages anyone that wants to help with this endeavor to stop by the store. The bookstore team monitors the shelf but they are also looking for volunteers. “Both girls came in with zero experience and faced designing challenges along the way but are pleased with their final project,” Blalock says. The students, says Jenn Blalock, technology education teacher, “designed, cut, and assembled the plant stand to donate to the bookstore as part of their technology education course.” The new plant shelf was built by seventh graders Emma Abramson and Anahi Matute of John Winthrop Middle School. The idea is not to buy plants but to share plants. The plant share is located outside the back of the bookstore (at 171 Main St.) and is accessible during the day, seven days a week.Īccording to Bennett, their team is working on propagating dozens of plants to share, but the project is supposed to be truly by-and-for the community with a “leave what you can, take what you need” ethos. ![]() Since a lot of people really love plants, we think this will be a popular service that fosters relationships.” Let us know how this access is important for you.According to Bennett, “the idea for this project, in addition to our Little Free Pantry, Freedge, and other community service is to be a beacon of hope in these trying times. Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Furthermore, it can be produced rapidly at high levels with minimal resources and reagents, making it ideal for production in low resource environments such as space. These results suggest that plant recombinant PTH-Fc exhibits a similar binding affinity and potency in a PTH1R activation assay compared to PTH. Its function was also confirmed in a cell-based receptor stimulation assay, where PTH-Fc was able to stimulate the PTH1R producing cyclic adenosine monophosphate (cAMP) with an EC 50 of (8.54 ± 0.12) x 10 -9 M, comparable to the EC 50 from the PTH (1-34) of 1.49 × 10 -8 M. ![]() The binding affinity between PTH-Fc and PTH1R was 2.30 × 10 -6 M, similar to the affinity between PTH (1-34) and PTH1R (2.31 × 10 -6 M). Once the PTH-Fc was purified, the amino acid sequence and the binding affinity to its target, PTH 1 receptor (PTH1R), was determined utilizing biolayer interferometry (BLI). The PTH-Fc accumulation profile in plant was established with a peak expression on day 5 post infiltration of 373 ± 59 mg/kg leaf fresh weight. Plant-based expression is well-suited for space medicine application given its low resource consumption and short expression timeline. In this study, PTH was produced in an Fc-fusion form via transient expression in plants, to improve the circulatory half-life which reduces dosing frequency and to simplify purification if needed. However, PTH proteins requires refrigeration, daily subcutaneous injection, and have a short shelf-life, limiting its use in a resource-limited environment, like space. ![]() Parathyroid Hormone or PTH (1-34) is an FDA approved treatment for osteoporosis, and may reverse microgravity-induced bone loss. With a typical bone mineral density loss of 1.5% per month of microgravity exposure, the chances for osteoporosis and fractures may endanger astronauts' health. Microgravity-induced bone loss is a main obstacle for long term space missions as it is difficult to maintain bone mass when loading stimuli is reduced.
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